Site-specific conjugation of IgG with Alexa Fluor® 488, 555 or 647.
GlyCLICK is a site-specific conjugation technology for IgG using Fc glycan remodeling and click-chemistry. The technology generates stable and homogenous antibody conjugates for IgG from several species and subclasses. Fc-glycan remodeling by complete deglycosylation of the antibody allows for site-specific conjugation using robust click-chemistry, resulting in a degree of label (DOL) or drug-antibody ratio (DAR) of 2.
GlyCLICK Fluorophore is available for site-specific labeling of 250 μg or 2 mg IgG with Alexa Fluor® 488, 555 or 647, and is suitable for in vitro cell imaging, immunohistochemistry and flow cytometry.
•Site-specific fluorophore-conjugation to IgG with a degree of labeling (DOL) of 2
•Conjugation of IgG with preserved immunoreactivity
•Improved imaging quality in fluorescence microscopy applications
