Glycan remodeling of human IgG with the G0, G1, G2 or G2S2 glycoform.
TransGLYCIT Remodeling is a platform technology for efficient transglycosylation of native human IgG in a few hours. The robust workflow transglycosylates the antibody Fc N-glycans using enzymatic remodeling, resulting in a homogenous pool of antibodies carrying a defined glycoform. The technology is available in kits to generate antibodies carrying the G0, G1, G2 or G2S2 glycan profiles.
TransGLYCIT Remodeling contains sufficient material to transglycosylate 1 mg human IgG. The glycan-remodeled sample will have the same degree of fucosylation as the original molecule. If you wish to remove core fucosylation, we recommend using TransGLYCIT Remodeling Afucosylated.
•Fast and efficient generation of human IgG with homogeneous glycoforms
•Facilitates functional analysis of specific glycan structures
•Reliable glycan remodeling achieved within a few hours
